Terf2ip是什么

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August undefined, 2024

WebTerf2ip-KO应用于研究领域:免疫系统,皮肤,信号转导,脂肪组织,DNA转录,蛋白质代谢,肝脏/胆道系统,内稳态/代谢,细胞组成,增长 ... Web21 Mar 2024 · Entrez Gene Summary for TERF2 Gene. This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative …

Single cell type - TERF2IP - The Human Protein Atlas

Web2 May 2024 · The aim of this study was to determine whether telomeric repeat-binding factor 2-interacting protein (TERF2IP), a member of the shelterin complex at the telomere, can regulate EC senescence, apoptosis, and activation simultaneously, and if so, by what molecular mechanisms. We found that d-flow induced p90RSK and TERF2IP interaction in … Web27 Jul 2011 · Function. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, … bookstands picture holders

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WebKazunori Tomita, Laura C. Collopy, in Encyclopedia of Cancer (Third Edition), 2024. The shelterin complex. The shelterin complex is made up of six family members that bind along the length of the telomere: TRF1 (TERF1), TRF2 (TERF2), RAP1 (TERF2IP), TIN2 (TINF2), TPP1 (ACD) and POT1 (POT1) (Fig. 2 B). TRF1 and TRF2 bind to the telomeric dsDNA. … WebThe TERF2IP pAb (1:50) was used to stain telomeres in the chromosome spreads; the pAb was used in triple labeling that included DAPI (to stain nuclei) and a SYCP3 antibody (SYC : ICC/IF: Mouse: Saha Bidisha, Zitnik Galynn, Johnson Simon et al. DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA ... WebTERF2IP - Explore an overview of TERF2IP, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. book stansted fast track

TERF2IP Antibody 生产供应商艾普蒂生物 - ChemicalBook

WebRAP1, also known as TERF2IP (telomeric repeat-binding factor 2-interacting protein 1) or DRIP5, is a 399 amino acid nuclear and cytoplasmic protein that contains one BRCT domain and one Myb-like domain. Belonging to the RAP1 family, RAP1 acts as both a regulator of telomere function and a regulator of transcription. While RAP1 does not bind DNA ... Web15 Apr 2024 · TERF2IP is also upregulated; this gene is involved in telomere length maintenance and transcription regulation . When cytoplasmic, TERF2IP associates with the l-kappa-B-kinase (IKK) complex and promotes IKK-mediated phosphorylation of RELA/p65, activating the NF-κB pathway and increasing expression of its target genes . book stand wall mountedWeb基因官方名：Terf2ip. 基因全名：telomeric repeat binding factor 2, interacting protein. 基因别名：Rap1. NCBI： 57321. MGI： 1929871. 染色体：Chr 8. 销售状态：IF (正常销售) 保存方式：冷冻. 品系背景：[N000013] C57BL/6JGpt. book stand vertical

"Web21 Jan 2024 · Western Blot: TERF2IP Antibody [NB100-56321] - Total protein from HeLa, SHSH-5Y, IMR-90 and MCF7 cells were separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-TERF2IP in 1% non-fat milk in TBST and detected with an anti-rabbit HRP … " - Terf2ip是什么

Terf2ip是什么

Web3 Oct 2015 · Germline CDKN2A mutations occur in 40 % of 3-or-more case melanoma families while mutations of CDK4, BAP1, and genes involved in telomere function (ACD, TERF2IP, POT1), have also been implicated in melanomagenesis. Mutation of the promoter of the telomerase reverse transcriptase (TERT) gene (c.−57 T>G variant) has been … WebDescription: Homo sapiens TERF2 interacting protein (TERF2IP), transcript variant 2, non-coding RNA. (from RefSeq NR_144545) RefSeq Summary (NM_018975): The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]. Gencode Transcript: …

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WebThe hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres … WebTRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at ...

WebFurther investigation determined that miR-1246 mediated H-GDE-induced M2 macrophage polarization by targeting TERF2IP to activate the STAT3 signaling pathway and inhibit the NF-κB signaling pathway. Our study elucidated a mechanism by which hypoxia and glioma … Webshelterin 复合体由端粒重复因子 1 (trf1)、端粒重复因子 2 (trf2)、端粒重复结合因子 2-相互作用蛋白（terf2ip，也称为 rap1）、端粒保护蛋白 1 (pot1)、trf1- 和 trf2-相互作用核蛋白 2 (tin2) 以及 tin2 结合蛋白 tpp1 组成。

Webterf2ip. single cell type tissues. adipose tissue bone marrow brain breast bronchus colon endometrium esophagus eye heart muscle. kidney liver lung lymph node ovary pancreas pbmc placenta prostate rectum. salivary gland skeletal muscle skin small intestine spleen stomach testis thymus tongue vascular. cell type proteome. WebTerf2ip em1(IMPC)Mbp /Terf2ip em1(IMPC)Mbp C57BL/6N-Terf2ip em1(IMPC)Mbp /MbpMmucd: decreased bone mineral density: J:211773: decreased red blood cell distribution width: J:211773: scaly skin: J:211773: Terf2ip Gt(XD108)Byg /Terf2ip + involves: 129P2/OlaHsd * C57BL/6 decreased susceptibility to bacterial infection induced …

WebAmong 510 melanoma families, ACD and TERF2IP mutations were identified in six and four families, respectively. The ACD gene ( adrenocortical dysplasia homologue ) is located on chromosome 16q22.1, and the encoded protein interacts with POT1 to mediate the control of telomere length and telomere end protection by regulating telomerase accessibility in …

WebTERF2IP Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TERF2IP Genome Browser, TERF2IP References TERF2IP - Explore an overview of TERF2IP, with a histogram displaying coding mutations, full tabulated details of all associated … harwood construction incWeb端粒重复结合因子 2 相互作用蛋白 (TERF2IP，也称 RAP1)，是 Shelterin 复合体的一个组分，它是一个多蛋白复合体，可结合端粒并将其组织成 T 环结构，以防止其被细胞视为 DNA 双链断裂 (1,2)。. Shelterin 复合物由 TERF2IP、TIN2 和 TPP2 蛋白组成，另外还有三个 … harwood constructionWebL2TP (Layer 2 Tunnel Protocol，第二层隧道协议)是一种协议本身不对通过的流量进行加密或实施保密措施的VPN协议。. 也正是因为这个原因，L2TP通常会结合IPsec加密套件（如下所述，类似于一种密码）来实现，以此提供安全性和隐私性。. L2TP/IPsec已经被内置于所 … harwood condominiums seattleWebn/a Ensembl ENSG00000166848 n/a UniProt Q9NYB0 n/a RefSeq (mRNA) NM_018975 n/a RefSeq (protein) NP_061848 n/a Lleoliad (UCSC) n/a n/a PubMed search n/a Wicidata Gweld/Golygu Bod dynol Protein sy'n cael ei godio yn y corff dynol gan y genyn TERF2IP yw TERF2IP a elwir hefyd yn Telomeric repeat-binding factor 2-interacting protein 1 a TERF2 … book star alliance bonus tripWeb21 Mar 2024 · TERF2IP TERF2 interacting protein [ (human)] Gene ID: 54386, updated on 10-Mar-2024. Summary. Enables G-rich strand telomeric DNA binding activity and phosphatase binding activity. Involved in several processes, including positive regulation of NIK/NF … book stansted expressWeb30 Jul 2024 · 1.软核：它是用硬件描述语言 (HDL)设计的独立功能的电路模块。. 从芯片设计程度来看，它只经过了RTL级设计优化和功能验证，通常是以HDL文本形式提交给用户。. 所以它不包含任何物理实现信息，因此，IP软核与制造工艺无关。. 软核相当于软件编程的 … book stansted express ticketsWebView mouse Terf2ip Chr8:112738030-112747160 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression book stansted airport parking