Kif18a inhibitor pipeline
WebVLS-1488 (KIF18A inhibitor) Synthetic Lethal. IND Enabling Web7 mrt. 2024 · Tuesday’s Amgen deal will add another promising asset to Volastra’s “growing pipeline of CIN-targeted therapeutics,” which includes VLS-1488, another KIF18A inhibitor discovered in-house using the company’s proprietary CINtech platform. Volastra will advance both sovilnesib and VLS-1488 through clinical development in 2024.
Kif18a inhibitor pipeline
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Web9 sep. 2024 · Volastra Therapeutics to Present Preclinical Data from KIF18A Inhibitor Program Targeting Chromosomally Unstable Tumors at FASEB Aneuploidy Conference September 9, 2024 Treatment with KIF18A inhibitor led to substantial, dose-dependent inhibition of tumor growth in multiple tumor... Load More In The News Web20 feb. 2015 · Using BTB-1, the first identified Kif18A inhibitor, as a lead compound, we synthesized a collection of derivatives. We demonstrate that some of the synthesized derivatives potently inhibited the ATPase activity of Kif18A with a half maximal …
WebBTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM. IC 50 & Target. IC50: 1.69 μM (Kif18A) [1] In Vitro. BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down ... Web6 apr. 2024 · Notably, the expression of kinesin-8 is often dysregulated in cancer and therefore may play an important role in that process. Interestingly, overexpression of KIF18A was reported to promote tumour formation, invasion and metastasis in colorectal cancer, while its knockdown triggered proliferation decrease in cancer cell lines, altogether …
Web9 sep. 2024 · KIF18A inhibitor on track to enter the clinic in 2H 2024 NEW YORK, September 9, 2024 – Volastra Therapeutics , an oncology company focused on exploiting chromosomal instability (CIN), today announced new data from its lead program, a … WebTwo known KIF18A inhibitors exist; however, their function is either limited (BTB-1) or the efficacy remains to be publicly validated (Amgen). In this thesis, a screening protocol involving fluorescent-based live cell imaging was formulated to test several small molecule compounds that were suspected to have compatibilities with a binding site on KIF18A.
Web15 apr. 2024 · When SDX-7320 was administered as a monotherapy at a dose of 8 mg/kg, it yielded a tumor growth inhibition rate (TGI) of 49%. Single-agent palbociclib, delivered at 20 mg/kg, elicited a TGI rate ...
can a microwave share an outletWebBackground: KIF18A is a kinesin assisting chromosome congression and alignment during mitosis. It is nonessential in normal, euploid cell division but essential for a subset of aneuploid cancer cells with high chromosomal instability (CIN-high). KIF18A knockdown … can a middle name be anythingWeb29 sep. 2024 · KIF18A is a protein that helps usher cells through mitosis by helping to align chromosomes. Normal cells can divide without KIF18A, but cells high in CIN have increased mitotic adaptation and errors, and are therefore, we believe, more dependent on KIF18A … fisher s04 pen refillWeb28 mei 2024 · TPS5600. Background: KIF18A is a mitotic kinesin motor protein that regulates chromosome positioning during cell division and is overexpressed in a subset of human cancers. TP53 mutant unstable aneuploid cancer cells with chromosomal … can a microwave superheat waterWeb4 sep. 2024 · KIF18A is overexpressed in various types of cancers, including but not limited to colon, breast, lung, pancreas, prostate, bladder, head, neck, cervix, and ovarian cancers. Further, genetic deletion or knockdown or inhibition of KIF18A affects mitotic spindle … can a microwave sit on top of a fridgeWebBackground:KIF18A is a kinesin assisting chromosome congression and alignment during mitosis. It is nonessential in normal, euploid cell division but essential for a subset of aneuploid cancer cells with high chromosomal instability (CIN-high). KIF18A knockdown in these cells leads to mitotic arrest, cy- tostasis and cell death. fisher s106Web9 sep. 2024 · Volastra Therapeutics In-Licenses Clinical Stage KIF18A Inhibitor and Secures $60 Million in Series A Funding to Further Advance Cancer-Focused Pipeline March 7, 2024 Financing led by founding investors Polaris Partners and ARCH Venture … can a microwave sit on top of a refrigerator