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Gas6 molecular weight

WebJan 18, 2024 · Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological … WebGas6 is present at around 0.2 nM (18 ng mL−1) in normal human serum or plasma [4], whereas the anticoagulant protein S is present at a thousand-fold higher concentration …

AXL Antibody (CPTC-AXL-2) - DSHB

WebApr 29, 2024 · Figure 1 shows the ROC curve referred to baseline Gas6 levels: considering an area under the curve of 0.653, we identified a Gas6 level of 58.0 ng/ml as the cut-off predicting a more severe disease evolution (53.33% sensitivity and 77.57% specificity), with a likelihood ratio of 2.38 (IQR: 1.46-3.87). Figure 1 WebGas6, which is maximally expressed at stage VI, may encode an autocrine factor for Sertoli cells because they express GAS6 receptors and respond to this cytokine with increased … herefordshire wildlife trust events https://estatesmedcenter.com

Gas6 is complexed to the soluble tyrosine kinase receptor Axl in …

WebGAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human … WebFor experiments assaying the requirement for a GAS6 gradient, cells containing 200 ng/ml GAS6 in DMEM-H were placed in the upper well of the chamber (GAS6/U&L). Following … WebMar 24, 2005 · Gas6-deficient mice were found to be resistant to thrombosis because of defective platelet function. Mouse Gas6 was demonstrated. Science Volunteer; ... Val, Ile and Tyr residues, essentially as described. 24 A molecular weight of 82 kDa was used in the calculations. The calculated molar extinction coefficient was found to be 83676 … matthew perry\u0027s dad pictures

GAS6 Arteriosclerosis, Thrombosis, and Vascular Biology

Category:Gas6/Axl Signaling Pathway in the Tumor Immune …

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Gas6 molecular weight

Molecular insights of Gas6/TAM in cancer development …

WebDec 1, 2024 · Finally, Axl and Gas6 are a key molecular system exploited by flaviviruses, such as Ebola (EBV) or Zika (ZIKV) viruses 12, 13. The Axl/Gas6 system is also involved … WebJan 18, 2024 · Published 18 Jan 2024 Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological activities are mediated by the interaction with three tyrosine kinase receptors: Tyro3, Axl, and MerTK, which are commonly and collectively abbreviated as TAM [ 4 ].

Gas6 molecular weight

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Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. WebFeb 3, 2024 · Here, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors.

WebDepositor: Clinical Proteomics Technologies for Cancer. Host Species: rabbit. Antigen Sequence: Positive Tested Species Reactivity: Human. Depositors Institution: National Cancer Institute. Antigen Molecular Weight: 98.3 kDa. Depositors Notes: AXLp is the receptor for growth factor GAS6. AXLp is also a host cell viral receptor. WebMar 23, 2024 · Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively referred to as TAM), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggreg …

WebMar 31, 2024 · Restoring Gas6 expression overcomes the stress-induced inhibition of HFSC activation and hair growth. ... the cellular and molecular mechanisms by which corticosterone regulates tissue ... WebOct 4, 2016 · For GAS6 kinetics upon AXL inhibition, cells were serum-starved overnight and preincubated with GI 50 non-Mes or GI 50 Mes concentrations of R428 for an hour, …

WebMar 24, 2005 · Gas6 was demonstrated to be present in human plasma, at a concentration determined to be 13 to 23 ng/mL (0.16 to 0.28 nM). Furthermore, plasma Gas6 levels …

WebMar 23, 2024 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic … herefordshire wildlife trust jobsWebAnti-GAS 6 antibody (ab136249) Datasheet SDS Reviews ( 3) Submit a question References (4) Key features and details Rabbit polyclonal to GAS 6 Suitable for: WB Reacts with: Human Isotype: IgG You may also be … herefordshire wildlife trust reservesWeb康朗生物为您提供硫胺素酶thtpa抗体的参数及2024年最新报价，厂家专业的硫胺素酶thtpa抗体售后服务团队，是您值得信赖的 ... matthew perry\\u0027s momWebGas6 contains 678 amino acids, which may be divided into five domains (Fig. 1A). The Gla domain is rich in γ-carboxyglutamic acid (Gla) residues. The corresponding Gla domain … matthew perry\u0027s interview with diane sawyerWebApr 10, 2024 · Activation of AXL Receptor and its ligand GAS6 is a major mechanism of acquired resistance to EGFR-TKIs therapy ... Moreover, due to its relatively large molecular weight, the concentration of drug in tumors is limited. Study suggested only a small portion of ADCs could reach to the tumor cells. matthew perry\u0027s mom and dadWebTaken together, our results identified GAS6-AS1 as a noveltumorsuppressorinLUAD andunraveleditsunderlying molecular mechanism in reprogramming glucose metabolism. GAS6-AS1 potentially may serve as a prognostic marker and therapeutic target in LUAD. INTRODUCTION matthew perry\\u0027s mother suzanne perryherefordshire wildlife trust shop